Peter A. Barbuti

Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons

The paper identifies compounds that restore morphology in Parkinson's disease neurons by targeting mitochondrial uncoupling.

The Role of Alpha Synuclein in Synucleinopathy: Impact on Lipid Regulation at Mitochondria ER Membranes

This paper investigates the role of alpha-synuclein in lipid regulation at MAM domains in synucleinopathies, showing disease-specific lipid alterations and Syn's impact on phosphatidylserine metabolism.

Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the SNCA gene

This study uses patient-specific midbrain organoids with SNCA triplication to show synaptic decline precedes dopaminergic neuron loss in Parkinson's disease.

Mitochondria-mitochondria interaction networks show altered topological patterns in Parkinson's disease

The paper analyzes mitochondria-mitochondria interaction networks in Parkinson's disease and finds altered topological patterns that correlate with clinical scores and can distinguish patients from controls.

Gene-corrected Parkinson's disease neurons show the A30P alpha-synuclein point mutation leads to reduced neuronal branching and function

This study shows that the A30P alpha-synuclein mutation in Parkinson's disease neurons reduces branching and function, with mitochondrial dysfunction and susceptibility to Rotenone.

IPSC-derived midbrain astrocytes from Parkinson's disease patients carrying pathogenic SNCA mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium release