Proteolytic Remodeling of Cargo Receptor Networks by RHBDL4 Tunes Secretory Pathway Flux
Susanne S Steigleder, Clara Neumann, Marina Tauber, Isabel Krämer, Monika Pesch, Julia Daniela Knopf, Julian Nüchel, Marius K. Lemberg
This study identifies RHBDL4 as a protease that remodels cargo receptor networks, modulating secretory pathway flux by cleaving ERGIC cargo receptors and affecting lysosomal protein secretion.
bioRxiv · Sep 2, 2026 · PreprintCell Biology