Marius K. Lemberg

This study identifies RHBDL4 as a protease that remodels cargo receptor networks, modulating secretory pathway flux by cleaving ERGIC cargo receptors and affecting lysosomal protein secretion.

The paper identifies a Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65, independent of RHBDL4 and utilizing autophagy and ESCRT components.

This study characterizes RHBDL4 enzymatic properties using an in vitro platform, identifying effective inhibitors and providing insights for drug development.

The paper describes a C-SWAT library for high-throughput tagging of yeast ORFs and validates it by tagging the yeast proteome with fluorescent proteins.