Julian Nüchel

Proteolytic Remodeling of Cargo Receptor Networks by RHBDL4 Tunes Secretory Pathway Flux

This study identifies RHBDL4 as a protease that remodels cargo receptor networks, modulating secretory pathway flux by cleaving ERGIC cargo receptors and affecting lysosomal protein secretion.

A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65

The paper identifies a Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65, independent of RHBDL4 and utilizing autophagy and ESCRT components.

A conserved cargo recognition mechanism establishes TANGO1 as a selective extracellular matrix cargo receptor

This study identifies TANGO1 as a selective ECM cargo receptor that directly recognizes specific collagen and fibrillin isoforms through a conserved tyrosine residue, independent of HSP47.

GRASP55 Safeguards Proper Lysosome Function by Controlling Sorting of Lysosomal Enzymes at the Golgi

This study identifies GRASP55 as a key regulator of lysosome function by controlling lysosomal enzyme sorting at the Golgi, revealing its role in lysosomal mTORC1 signaling and potential involvement in lysosomal storage disorders.

The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity

This study identifies CYLD as a deubiquitinase that inhibits mTOR activity by removing K63-linked ubiquitin chains, linking its loss to mTOR hyperactivation and disease.