Selective loss of the GABAAα1 subunit from Purkinje cells is sufficient to induce a tremor phenotype
Angela K. Nietz, Chris Krook-Magnuson, Haruna Gutierrez, Julia Klein, Clarke Sauve, Isaac Hoff, Zoé Christenson Wick, Esther I. Krook-Magnuson
This study shows that selectively knocking out the GABAAα1 subunit in Purkinje cells induces a tremor phenotype, similar to Essential Tremor, without affecting survival or motor function.
Journal of Neurophysiology · Sep 9, 2020Peer-reviewedNeuroscience