Huntingtin expression influences spontaneous seizure disorder susceptibility in FVN/B mice
Jeremy M. Van Raamsdonk, Hilal Al-Shekeli, Laura A. Wagner, Timothy William Bredy, Laura Chan, Jacqueline Pearson, Claudia Schwab, Zoe Murphy, Rebecca S. Devon, Ge Lu, Michael Steffen Kobor, Michael R. Hayden, Blair R. Leavitt
This study shows that altering huntingtin levels affects seizure susceptibility in FVB/N mice, with over-expression preventing seizures and reduction increasing their frequency.
bioRxiv · Oct 18, 2022 · PreprintNeuroscience