Michael Steffen Kobor

This study shows that ETI treatment in CF patients reduces epigenetic age acceleration, linked to inflammation and disease activity.

The paper investigates how DNA methylation in peripheral blood relates to immune cell type composition in the frontal brain using epigenome-wide association studies and machine learning.

This study examines DNA methylation in children from a Congo Basin community, linking it to family dynamics like parental conflict and father caregiving, and identifies associated biological pathways.

This study examines how prenatal air pollution exposure affects DNA methylation in cord blood and its link to childhood wheeze, finding some epigenetic changes are partially buffered by maternal diet.

This study shows exercise induces methylome and transcriptome changes in skeletal muscle, independent of COPD and age, with some changes linked to inflammation and others to tissue remodeling.

RAMEN dissects gene-environment contributions to DNA methylome variability in cord blood, finding genetics explains the largest proportion of DNAme variance.

The paper examines how cellular heterogeneity in saliva affects DNA methylation and epigenetic age acceleration, showing differences based on cell type composition and reference panels.

This study examines differences between Infinium MethylationEPIC v1 and v2, showing high array-level concordance but probe-level variation, and recommends accounting for version differences in analyses.

The paper describes a germline variant in IKZF2 causing immune dysregulation, including AIHA and atopic dermatitis, and reports single-cell RNA sequencing findings on T cell dysfunction.

CellsPickMe improves blood cell deconvolution in longitudinal DNA methylation studies by integrating cord and adult references, enhancing accuracy across developmental stages.

The paper identifies population-specific DNA methylation patterns in African and European populations and links them to genetic variants and disease-related genes.

The paper presents a genomic data resource from a caloric restriction trial, including SNP genotypes and multi-omic longitudinal data from multiple tissues.

The paper identifies evolutionarily conserved DNA methylation sites in great apes and shows their association with cancer but not other diseases.

This study shows that using updated reference genomes like T2T-CHM13 and pangenomes increases CpG detection in DNA methylation analysis and improves probe specificity in arrays, leading to more accurate findings in cancer studies.

This study identifies Rtt107's role in preventing genome instability by interacting with Rad55 and Slx4, showing distinct functions in limiting crossover events and maintaining rDNA stability.

This study identifies DNA methylation sites in PBMCs associated with cumulative family adversity in children, suggesting PBMC DNAm as a marker for biological embedding of cumulative adversity.

The paper develops universal epigenetic clocks that accurately estimate age across mammalian tissues using DNA methylation data from 185 species.

The paper introduces a pruning and thresholding method for methylation risk scores to improve prediction across multi-ancestry populations, showing better performance than simple thresholding.

This study identifies persistent DNA methylation changes linked to prenatal NO2 exposure in early childhood and links some changes to wheeze and atopy.

The paper develops DNAmFitAge, a biological age indicator that integrates physical fitness metrics with epigenetic clocks to assess aging and health risks.

This study shows that altering huntingtin levels affects seizure susceptibility in FVB/N mice, with over-expression preventing seizures and reduction increasing their frequency.

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

The paper introduces a method called sail to detect non-linear interactions between a key exposure variable and high-dimensional data, showing it outperforms existing methods in prediction and support recovery.

The paper identifies a human with complete NFAT1 deficiency, revealing its role in joint contractures, osteochondromas, and B cell malignancy through single-cell omic analyses.

This study analyzes DNA methylation changes in humans undergoing calorie restriction, finding CR-induced DNAm changes opposite BMI and smoking associations and aligned with aging-related CpG sites.

The paper examines epigenetic age acceleration (EAA) across multiple tissues in HIV-infected individuals, finding tissue-specific correlations and associations with clinical conditions and sex.

This study identifies DNA methylation and hydroxymethylation changes in dopaminergic neurons overexpressing alpha-synuclein variants, linking them to altered gene expression in PD-related pathways.

This study identifies Gcr2 as a Cdk8 substrate, showing its phosphorylation is critical for activating glycolysis genes.

This study finds that internalizing symptoms in early childhood predict higher epigenetic age acceleration at age 6, which is linked to later internalizing symptoms.

This study uses multi-omic profiling of blood samples from ALD patients to identify molecular markers predictive of cerebral demyelination, but finds no statistically significant markers due to high inter-individual variation.