Timothy William Bredy

The paper identifies C/D box snoRNAs, including orphans, that are involved in fear-related memory processes in mice by modulating mRNA methylation and synaptic function.

This study identifies Vaultrc5 as a noncoding RNA that regulates synaptic vault trafficking and RNA cargo dynamics, impacting learning and memory.

This study shows that early-life stress induces memory deficits by altering the m6A RNA epitranscriptome through FTO downregulation, affecting protein synthesis.

PSD-95-Halo-seq combined with long-read sequencing reveals sex-specific RNA isoform remodeling in excitatory synapses following fear learning.

The paper identifies local translation of circular RNAs in the prefrontal cortex of mice, revealing a micropeptide involved in synaptic activity and memory.

The paper identifies a brain-enriched extrachromosomal circular DNA (ecDNA) that regulates plasticity-related genes and is linked to fear memory stability in mice.

The paper uses Oxford Nanopore DRS to profile m6A modifications at the isoform level in human brain regions, identifying thousands of m6A sites and region-specific patterns.

The paper shows DNA G-quadruplex regulates gene expression in neurons, affecting memory formation and fear extinction.

The paper shows that inhibiting the CPEB3 ribozyme increases CPEB3 protein and enhances memory by promoting mRNA polyadenylation and translation.

The paper identifies a lncRNA, Gas5, involved in fear extinction by regulating RNA granule trafficking and clustering at synapses in mice.

The paper identifies synapse-enriched lncRNAs in mouse hippocampus and shows their roles in synapse development and fear memory consolidation.

This study shows that altering huntingtin levels affects seizure susceptibility in FVB/N mice, with over-expression preventing seizures and reduction increasing their frequency.

The paper shows that inhibiting circRNA Cdr1as in the infralimbic prefrontal cortex of mice impairs fear extinction memory.

The paper identifies synapse-specific m6A RNA readers and their role in fear extinction memory consolidation through RNA immunoprecipitation and sequencing in mice.

The paper identifies ADRAM, an experience-dependent lncRNA that interacts with 14-3-3 to regulate Nr4a2 expression and fear extinction memory in mice.

The paper shows that the CPEB3 ribozyme regulates hippocampal-dependent memory by modulating mRNA maturation and translation of plasticity-related genes.

This study shows ADAR1 interacts with Z-DNA during fear extinction learning, affecting RNA editing and memory flexibility.

This study shows that m6dA accumulation in DNA of prefrontal cortical neurons is linked to fear extinction learning and gene expression.

This study shows that knocking down Piwil1 and Piwil2 in the mouse hippocampus enhances contextual fear memory without affecting anxiety.

This paper identifies Gadd45g as a regulator of IEG expression dynamics and memory consolidation through DNA methylation changes during fear learning.

This study shows that ING1 regulates activity-induced gene expression in cortical neurons by interacting with other epigenetic factors and affecting synaptic plasticity-related genes.