Positive Feedback Regulation of fzd7 Expression Robustly Shapes Wnt Signaling Range in Early Heart Development
Takayoshi Yamamoto, Yuta Kambayashi, Boni Anatole Afouda, Yuta Otsuka, Claudiu Giuraniuc, Tatsuo Michiue, Stefan Hoppler
The paper shows that feedback regulation of fzd7 expression and sFRP1 localization via heparan sulfate restrict Wnt signaling to shape a thin pericardium during heart development.
eLife · Jun 30, 2022Peer-reviewedDevelopmental Biology