Tatsuo Michiue

This study uses atomic force microscopy to map single-cell stiffness in Xenopus laevis embryos, revealing mechanical differences between animal and vegetal hemispheres during early development.

The paper identifies NAc-HS binding motifs in Cerberus and shows they expand BMP4 distribution and signaling by relocating BMP4 from NS-HS to NAc-HS.

The paper shows that feedback regulation of fzd7 expression and sFRP1 localization via heparan sulfate restrict Wnt signaling to shape a thin pericardium during heart development.

This paper introduces a machine learning method for cell segmentation in developing embryos, showing improved accuracy over existing techniques.