Fed-batch production of antiviral OP7 chimera defective interfering influenza A particles
Wiebke Holste, Sascha Young Kupke, Claudius Seitz, Udo Reichl, Holger Ziehr
This paper develops a fed-batch production process for OP7 chimera DIPs, achieving higher virus titers and bioactivity compared to batch production, with potential for GMP manufacturing.
bioRxiv · Oct 1, 2026 · PreprintBioengineering