Udo Reichl

This paper develops a fed-batch production process for OP7 chimera DIPs, achieving higher virus titers and bioactivity compared to batch production, with potential for GMP manufacturing.

This study engineers a modified DIP by truncating NS1 to enhance antiviral activity, showing improved inhibition of IAV replication and IFN response.

This paper develops a multiscale model of IAV and OP7 coinfection, revealing MOI-dependent antiviral mechanisms and predicting therapeutic efficacy.

This study demonstrates that OP7, an unconventional influenza A defective interfering particle, effectively inhibits viral replication in human lung cells through both direct interference and IFN induction, supporting its potential as an antiviral agent.

This paper improves anaerobic digestion models by integrating metaproteomics data to better represent microbial functions and dynamics in a two-step digester system.

The paper compares proteomic changes in two monoclonal MDCK cell lines infected with influenza A virus to identify factors associated with high viral yield.

This paper develops a workflow using BONCAT and click chemistry to detect and isolate phage-host complexes, validated with E. coli and lambda phage.

This study identifies sulfated and O-acetylated N-glycans at specific sites in human IgA using a targeted N-glycoproteomic approach, revealing their potential as biomarkers and therapeutic targets.

This study compares glycosylation, infectivity, and neutralization sensitivity of SIV produced in macrophages versus CD4+ T cells, revealing differences in glycan profiles and their impact on viral spread and antibody neutralization.

The paper develops a workflow to enrich newly synthesized proteins in microbial communities using BONCAT and click chemistry, demonstrating its application in tracing microbial activity.

The paper develops an improved N-glycoproteomic workflow to analyze low-abundant glycoproteins in human blood plasma, enabling the identification of 1,929 N-glycopeptides and 942 N-glycosites.

The paper introduces a user-friendly web tool for assigning microbial community data to metabolic pathways, enabling pathway creation and automated data mapping.

This study shows that defective interfering particles (DIPs) primarily exert antiviral activity through interferon (IFN) system activation rather than suppression of viral replication.

The paper describes an in-vitro glycoengineering approach to modify N-glycans on recombinant SARS-CoV-2 spike glycoprotein to mimic mammalian cell-derived glycoforms.