Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis
Aoise O’Neill, Norashikin Zakaria, Hannah Egan, Shania M. Corry, Courtney Bull, Niamh A. Leonard, Clodagh O'Meara, Linda Howard, Anastasija Walsh, Eileen Reidy, Jenny Che, Peng Li, Lizhi Cao, Laurence John Egan, Thomas Ritter, , Aideen E. Ryan
This study shows stromal cell sialylation via the Sialic acid/Siglec axis suppresses innate immune cell function in CRC, and targeting this pathway restores immune activity.
Journal for ImmunoTherapy of Cancer · Oct 1, 2025Peer-reviewedCancer Biology