Author
Queen's University BelfastORCID 0000-0002-3120-9144Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Shania M. Corry, Svetlana S. Sakhnevych, Noha Ehssan Mohamed…·Philip D. Dunne
This study shows that poly(I:C) treatment in CMS4 colorectal tumors induces a pro-inflammatory, CMS1-like regenerative state and identifies biomarkers for predicting therapeutic response.
Alessandra I. Riggio, Kerri Sweeney, Robin Shaw…·Karen Blyth
This study shows that Runx1 and Runx2 suppress Wnt/β-catenin-driven mammary tumourigenesis, with combined loss leading to increased tumour development and oncogenic pathway activation.
Aoise O’Neill, Norashikin Zakaria, Hannah Egan…·Aideen E. Ryan
This study shows stromal cell sialylation via the Sialic acid/Siglec axis suppresses innate immune cell function in CRC, and targeting this pathway restores immune activity.
Phimmada Hatthakarnkul, Natalie C. Fisher, Leonor Schubert Santana…·Joanne Edwards
This study identifies TNF- and TGF-β signaling as drivers of tumour budding in CRC, linked to poor prognosis and an immunosuppressive microenvironment.
Catriona A. Ford, Dana Koludrović, Patricia P. Centeno…·Andrew D. Campbell
This study identifies a druggable PREX2/RAC1/PI3Kβ signalling axis in BRAF-mutant melanoma that confers resistance to therapies and can be targeted to improve treatment outcomes.
Courtney Bull, Ryan M. Byrne, Natalie C. Fisher…·Sudhir B. Malla
This study compares GSEA tools and finds single sample approaches better capture biological distinctions than pairwise methods in cancer recurrence analysis.