Aideen E. Ryan

Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.

Immunological responses to hydrogel-aided induced pluripotent stem cell-derived dopaminergic progenitor transplants in immunodeficient versus cyclosporine immunosuppressed rats.

This study compares immune responses to dopaminergic progenitor transplants in immunodeficient and cyclosporine-immunosuppressed rats, finding that hydrogel benefits depend on immunosuppression adequacy.

Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state

This study shows that poly(I:C) treatment in CMS4 colorectal tumors induces a pro-inflammatory, CMS1-like regenerative state and identifies biomarkers for predicting therapeutic response.

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis

This study shows stromal cell sialylation via the Sialic acid/Siglec axis suppresses innate immune cell function in CRC, and targeting this pathway restores immune activity.

Investigation of immune response to Mesenchymal Stromal Cell-derived Extracellular Vesicles in the cancer setting

This study investigates whether MSC-EVs elicit an immune response in tumor-bearing mice and finds no significant immune activation, supporting their immune privilege and therapeutic potential.

Evaluation of Gene Set Enrichment Analysis (GSEA) tools highlights the value of single sample approaches over pairwise for robust biological discovery.

This study compares GSEA tools and finds single sample approaches better capture biological distinctions than pairwise methods in cancer recurrence analysis.