Nuclear βactin dependent chromatin accessibility governs stem cell pluripotency and extracellular matrix gene programs to maintain cellular biomechanics for cell lineage decisions
Colin Campbell, Nadine Hosny El Said, Amani Al Nuairi, Loganathan Palanikumar, Christopher Breunig, Muhammedin Deliorman, Zahraa Alraies, Esha Sadiq, Sabrina C. Desbordes, Liaqat Ali, Muhammad Shiraz Ali, Giuseppe Saldi, Martin J. Lohse, Mazin M. Magzoub, Mohammad Ameen Qasaimeh, Piergiorgio Percipalle
This study shows nuclear βactin regulates chromatin accessibility and ECM mechanics to maintain pluripotency and lineage decisions in mESCs.
bioRxiv · Sep 10, 2026 · PreprintCell Biology