Martin J. Lohse

Nuclear βactin dependent chromatin accessibility governs stem cell pluripotency and extracellular matrix gene programs to maintain cellular biomechanics for cell lineage decisions

This study shows nuclear βactin regulates chromatin accessibility and ECM mechanics to maintain pluripotency and lineage decisions in mESCs.

Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors

The paper develops sensitive FRET biosensors to visualize CaMKII activity dynamics in living cells and demonstrates their use in cultured and primary cells, including neurons and cardiomyocytes.

MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor

This study shows that MRAP2 modifies MC4R signaling and oligomerization, enhancing G protein signaling while reducing beta-arrestin2 recruitment and receptor internalization.

Disruption of basal CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms

This study shows that disrupting CXCR4 oligomers in lymphoid cancers reduces migration, survival signaling, and tumor growth, while sensitizing cells to venetoclax.

Fluorescence spectroscopy of low-level endogenous β-Adrenergic Receptor expression at the plasma membrane of differentiating human iPSC-derived cardiomyocytes

The paper uses fluorescence spectroscopy to track β1/2-AR membrane abundance in differentiating hiPSC-derived cardiomyocytes and compares it to mRNA levels in WT and knock-in clones.

Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

This study identifies subtype-specific differences in transmembrane domain interactions that influence metabotropic glutamate receptor activation.

Structural and functional characterization of allatostatin receptor type-C of Thaumetopoea pityocampa revealed the importance of Q2716.55 residue in G protein-dependent activation pathway

The paper characterizes the structure and function of AstR-C in T.pit, identifying Q2716.55 as critical for G protein-dependent activation.

Visualization of class A GPCR oligomerization by image-based fluorescence fluctuation spectroscopy

This study uses image-based fluorescence fluctuation spectroscopy to assess oligomerization of Class A GPCRs in intact cells, finding that β2-AR shows slight oligomerization while others are predominantly monomeric.