Circadian Dysregulation in Aging Alters Senescence and Inflammatory Pathways in a Sex- and Time-of-Day Dependent Manner
Gretchen T. Clark, Yue Zhao, Robyn E. Reeve, Colleen M. Farley, Courtney Willey, Susan Sheehan, Samantha Spellacy, Alicia Warren, Abigail Brackett, Nadia A Rosenthal, Ron Korstanje
This study shows that aging disrupts circadian rhythms, leading to sex- and time-of-day-dependent changes in senescence and inflammatory pathways in mice.
bioRxiv · Mar 8, 2026 · PreprintGenetics