Yue Zhao

Oncohistone inhibition reshapes tumor-microenvironment communication in Diffuse Midline Glioma (DMG)

This study shows that H3K27M oncohistone reshapes the tumor microenvironment in DMG by altering neuronal interactions and immune signaling, suggesting it as a therapeutic target.

Site-Specific Inhibition of Translation Initiation via 2'-O-methylation

The paper identifies 2'-O-methylation as a site-specific inhibitor of translation initiation by disrupting hydrogen bonds between mRNA start codons and 18S rRNA.

The live attenuated DGAT1-knockout whole-cell Toxoplasma vaccine confers protective immunity against acute and chronic toxoplasmosis

This paper develops a live-attenuated Toxoplasma vaccine by knocking out DGAT1, showing it provides long-term protection against both acute and chronic toxoplasmosis.

The atypical IκB factor IκBδ enhances CD8 T cell accumulation and effector functions in solid tumors

This study identifies IκBδ as a factor that enhances CD8 T cell accumulation and effector functions in solid tumors by overcoming constraints on T cell survival and cytotoxic capacity.

Circadian Dysregulation in Aging Alters Senescence and Inflammatory Pathways in a Sex- and Time-of-Day Dependent Manner

This study shows that aging disrupts circadian rhythms, leading to sex- and time-of-day-dependent changes in senescence and inflammatory pathways in mice.

Single cell analysis of Barrett's esophagus and carcinoma reveals cell types conferring risk via genetic predisposition

The paper uses single cell RNA-sequencing and genome-wide association study data to identify cell types and processes involved in Barrett's esophagus and esophageal adenocarcinoma risk.

Esophageal adenocarcinoma relapse after chemoradiation is dominated by a basal-like subtype

The paper identifies a basal-like subtype in esophageal adenocarcinoma associated with relapse after chemoradiation and poor survival.

Population genomics reveals extensive inbreeding and purging of mutational load in wild Amur tigers

This study finds higher inbreeding and purging of mutational load in wild Amur tigers compared to captive individuals, suggesting purifying selection reduces deleterious alleles in wild populations.