Ron Korstanje

Fatty acid desaturation guides cellular decisions between ferroptosis and cellular senescence

The paper shows that fatty acid desaturation, specifically DGLA, influences cellular decisions between ferroptosis and senescence, with implications for aging and obesity.

APOE is a presynaptic protein that accumulates with age and modulates neurotransmitter release

This study identifies APOE as a presynaptic protein enriched in aged female mice, showing it modulates neurotransmitter release and affects synaptic function.

Spoti-find: A novel, open-source void spot assay image analysis tool

Spoti-find is an open-source tool for analyzing void spot assays, introducing new metrics and improving usability and accuracy in urinary behavior studies.

Circadian Dysregulation in Aging Alters Senescence and Inflammatory Pathways in a Sex- and Time-of-Day Dependent Manner

This study shows that aging disrupts circadian rhythms, leading to sex- and time-of-day-dependent changes in senescence and inflammatory pathways in mice.

Genetic regulation of fasting-induced longevity effects

This study shows that genetic background and sex influence responses to intermittent fasting in mice, with effects on lifespan and health outcomes varying across strains.

Analysis of lifespan across Diversity Outbred mouse studies identifies multiple longevity-associated loci

This study identifies six longevity-associated loci in Diversity Outbred mice through a genetic meta-analysis of lifespan data from three studies, explaining over half of the heritable variation in lifespan.

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

Longitudinal Fragility phenotyping predicts lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice

This study uses frailty phenotyping to predict lifespan and age-associated morbidity in mice, finding it has significant predictive power but not sufficient reliability for advanced lifespan prediction.

Cell morphology QTL reveal gene by environment interactions in a genetically diverse cell population

The paper identifies cell morphology quantitative trait loci (cmQTL) in fibroblasts exposed to arsenic, revealing gene-environment interactions and genetic regulation of oxidative stress responses.

Comprehensive single cell aging atlas of mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer

This study creates a single-cell aging atlas of mouse mammary tissues, identifying shared epigenomic and transcriptomic changes between aging and cancer.

Global and tissue-specific aging effects on murine proteomes

The paper analyzes proteomic changes across 10 tissues in mice at different ages, finding age-related increases in immune proteins and tissue-specific alterations in protein complexes.

Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging

The paper identifies the transcriptional activation of Jun and Fos genes in the AP-1 complex as a conserved aging signature in immune cells, contributing to inflammaging across mouse strains and humans.

Genome-wide transcript and protein analysis reveals distinct features of aging in the mouse heart

The paper analyzes transcriptome and proteome data from aged mouse hearts to identify molecular changes associated with aging, revealing distinct biological processes and genetic loci influencing age-related changes.

Functional Characterization of Lipid Regulatory Effects of Three Genes Using Knockout Mouse Models

The paper identifies three causal lipid genes using Mendelian randomization and confirms their effects through mouse knockout studies and RNA-seq analysis.

3-hydroxyanthranilic acid - a new metabolite for healthy lifespan extension

This study identifies 3-hydroxyanthranilic acid (3HAA) as a metabolite that extends lifespan and improves health in C. elegans and mice by reducing oxidative stress and activating the Nrf2/SKN-1 pathway.

Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney

This study profiles mRNA and protein levels in aging kidneys, finding that protein changes reveal more extensive and functionally significant aging-related alterations than mRNA.

Integration of heterogeneous functional genomics data in gerontology research identifies genes and pathway underlying aging across species

The paper integrates heterogeneous functional genomics data across species to identify genes and pathways underlying aging, finding Cd63 as a key gene with lifespan-extending effects in C. elegans.

Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation.

This study identifies 169 differentially expressed genes in black bear kidneys during hibernation, highlighting potential mechanisms for avoiding kidney damage.

Hierarchical Analysis of Multi-mapping RNA-Seq Reads Improves the Accuracy of Allele-specific Expression

EMASE improves ASE estimation by hierarchically allocating multi-mapping RNA-Seq reads, showing better performance than standard methods in simulations and detecting ASE in F1 hybrid mice.