Systematic dissection of epigenetic age acceleration in normal breast tissue reveals its link to estrogen signaling and cancer risk
Mary Elizabeth Sehl, Wenbin Guo, Collin Farrell, Natascia Marino, Jill E. Henry, Anna Maria Storniolo, Jeanette C. Papp, Jingyi Jessica Li, Steve Horvath, Matteo A. Pellegrini, Patricia A. Ganz
The paper evaluates epigenetic clocks in normal breast tissue, identifies age acceleration linked to estrogen signaling and cancer risk, and highlights cellular heterogeneity's role in age estimation.
bioRxiv · Oct 31, 2024 · PreprintBioinformatics