Steve Horvath

Systemic control and inter-organ communication of ovarian aging

This study shows ovarian aging can shift in both directions depending on the systemic environment through inter-organ communication and molecular changes.

Transplanted hearts assimilate the recipient's biological age

DNA methylation clocks show heterochronic heart grafts shifting toward recipient age in syngeneic mice and 11 human recipients, while recipient mouse native heart, liver and blood show no consistent change.

Effects of long-term fasting: longitudinal epigenetic responses in humans

This study examines the epigenetic effects of prolonged fasting in humans, finding changes in DNA methylation and epigenetic aging clocks linked to metabolic responses.

Large-scale Perturbation of Systems Biology-Derived Genes Reveals Modifiers of HD-associated Transcriptomic Networks and Pathology

The paper uses genetic perturbations to identify modifiers of HD-associated transcriptomic networks and pathology in mice and patient-derived neurons.

Compatibility and comparative analysis of chronological and biological aging between the legacy 450K and the EPIC v2.0 arrays

The paper compares epigenetic aging estimates between the 450K and EPICv2 arrays, finding that some clocks are affected by missing probes, but overall correlations remain strong.

Beyond the Genotype: A Multi-Omic Analysis of APOEe4's Role in Alzheimer's Disease

This paper investigates how APOEe4 influences molecular changes in Alzheimer's disease through proteomic, epigenetic, and genetic analyses of post-mortem brain samples, identifying key proteins and epigenetic markers associated with risk and resilience.

Sex-specific non-linear DNA methylation trajectories across aging predict cancer risk and systemic inflammation

DNA Methylation Ageing Atlas Across 17 Human Tissues

The paper creates a DNA methylation aging atlas across 17 human tissues, identifying conserved and tissue-specific aging signatures and potential therapeutic targets.

Dental aging offers new insights to the first epigenetic clock for common dolphins (Delphinus delphis)

The paper develops the first species-specific epigenetic clock for common dolphins using DNA methylation data from stranded and bycaught individuals, showing consistent underestimation in older dolphins.

Molecular signatures of longevity identify compounds that extendmouse lifespan and healthspan

The paper identifies compounds that extend mouse lifespan and healthspan using a biomarker-driven platform integrating gene expression, chemical screening, and lifespan studies.

Cross-species and tissue imputation of species-level DNA methylation samples across mammalian species.

The paper develops CMImpute, a method to impute DNA methylation data for unprofiled species-tissue combinations, achieving strong correlation with observed values and imputing 19,786 new combinations.

Epigenetic Clocks Uncover the Natural History of Ageing in Wild Mice

This paper develops an epigenetic clock for wild wood mice to estimate age and ageing rates, showing slower ageing in supplemented and parasite-treated individuals.

A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan

This study shows that inducing a torpor-like state in mice slows blood epigenetic aging and improves healthspan by reducing core body temperature.

Epigenomic insights into extreme longevity in the world's oldest terrestrial animal, Jonathan

The paper analyzes the DNA sequence and methylome of Jonathan, a 192-year-old giant tortoise, to identify epigenomic features associated with extreme longevity.

The CALERIE™ Genomic Data Resource

The paper presents a genomic data resource from a caloric restriction trial, including SNP genotypes and multi-omic longitudinal data from multiple tissues.

Systematic dissection of epigenetic age acceleration in normal breast tissue reveals its link to estrogen signaling and cancer risk

The paper evaluates epigenetic clocks in normal breast tissue, identifies age acceleration linked to estrogen signaling and cancer risk, and highlights cellular heterogeneity's role in age estimation.

CpGPT: a Foundation Model for DNA Methylation

CpGPT is a foundation model for DNA methylation analysis that outperforms specialized models in aging-related tasks and can impute methylation profiles across diverse conditions.

Axolotl epigenetic clocks offer insights into the nature of negligible senescence

This study develops epigenetic clocks for axolotls, revealing biphasic age prediction during early life but not later, and highlights methylome stability across lifespan.

Loss of H3K9 trimethylation leads to premature aging

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

COGNITIVE REJUVENATION IN OLD RATS BY HIPPOCAMPAL OSKM GENE THERAPY

This study shows that OSKM gene therapy in old rats improves spatial learning and memory, reduces epigenetic age, and reverses age-related DNA methylation changes in the hippocampus.

Msh3 and Pms1 Set Neuronal CAG-repeat Migration Rate to Drive Selective Striatal and Cortical Pathogenesis in HD Mice

This study identifies Msh3 and Pms1 as genetic drivers of CAG-repeat migration in HD mice, leading to selective striatal and cortical pathogenesis.

Cross Tissue DNAm Biomarker Prediction using Transfer Learning

This study uses transfer learning to predict blood DNA methylation biomarkers from saliva data, improving accuracy over traditional methods for 20 out of 26 biomarkers.

MammalMethylClock R package: software for DNA Methylation-Based Epigenetic Clocks in Mammals

The paper introduces an R package for constructing and evaluating DNA methylation-based epigenetic clocks in mammals.

Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease risk

The paper investigates epigenetic age acceleration in schizophrenia, finding age- and sex-specific effects and associations with polygenic risk scores.

Causality-Enriched Epigenetic Age Uncouples Damage and Adaptation

The paper introduces causality-enriched epigenetic clocks, DamAge and AdaptAge, to track detrimental and adaptive methylation changes linked to aging, showing their association with adverse outcomes and beneficial adaptations.

ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age

The paper compares DNA methylation age in four premature aging mouse models, finding ERCC1 mice show the most significant increase in epigenetic age.

In vivo reprogramming leads to premature death due to hepatic and intestinal failure.

This study shows that continuous in vivo reprogramming with OSKM causes hepatic and intestinal failure, leading to premature death, but a new mouse strain reduces these effects.

Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction

This study shows that young porcine plasma treatment reduces epigenetic age in multiple rat organs and improves physiological function.

Histone mark age of human tissues and cells

The paper develops histone mark-based age prediction models across tissues, showing comparable accuracy to DNA methylation predictors and identifying key developmental pathways involved in aging.

Biological age is increased by stress and restored upon recovery

This study shows biological age can increase with stress and decrease with recovery, using epigenetic clocks in mice and humans.