Patricia A. Ganz

This study compares DNA methylation profiles of breast tumors, adjacent normal tissues, and healthy controls to identify epigenetic differences and their association with estrogen receptor status.

The paper evaluates epigenetic clocks in normal breast tissue, identifies age acceleration linked to estrogen signaling and cancer risk, and highlights cellular heterogeneity's role in age estimation.

This study identifies seven novel genetic loci associated with high-grade serous ovarian cancer risk using a large-scale GWAS and develops polygenic scores for improved risk prediction.

This study quantifies genetic correlations between six solid cancers and other diseases using GWAS data, finding shared heritability and functional enrichment in regulatory regions.