Mitochondrial DNA Mutations Determine Favourable Molecular Responses to Targeted Kinase Inhibitor Therapy and Impair Oxidative Phosphorylation
Ilaria Stefania Pagani, Vaidehi Krishnan, John F. Ouyang, Chung Hoow Kok, BeiJun Chen, Kian Leong Lee, Cong M Pham, Paul Wang, Elyse C. Page, Phuong Dang, Verity A Saunders, Jane James, Kelly SY Lim, Naranie Shanmuganathan, Agnes S. M. Yong, , David M. Ross
This study shows that mitochondrial DNA mutations are linked to better responses to kinase inhibitor therapy and reduced oxidative phosphorylation in CML patients.
bioRxiv · Jul 15, 2025 · PreprintCancer Biology