Author

Vaidehi Krishnan

National University of SingaporeORCID 0000-0002-5028-6567Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

S. Tiong OngiD· 3 shared Agnes S. M. YongiD· 2 shared Charles T. H. ChuahiD· 2 shared David T. O. YeungiD· 2 shared Kian Leong LeeiD· 2 shared Naranie ShanmuganathaniD· 2 shared Shyam PrabhakariD· 2 shared Timothy P. HughesiD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

S. Tiong OngORCID

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3 papers

Recent·Most cited

Mitochondrial DNA Mutations Determine Favourable Molecular Responses to Targeted Kinase Inhibitor Therapy and Impair Oxidative Phosphorylation

Ilaria Stefania Pagani, Vaidehi Krishnan, John F. Ouyang, Chung Hoow Kok, BeiJun Chen, Kian Leong Lee, Cong M Pham, Paul Wang, Elyse C. Page, Phuong Dang, Verity A Saunders, Jane James, Kelly SY Lim, Naranie Shanmuganathan, Agnes S. M. Yong, , David M. Ross

This study shows that mitochondrial DNA mutations are linked to better responses to kinase inhibitor therapy and reduced oxidative phosphorylation in CML patients.

bioRxiv · Jul 15, 2025 · PreprintCancer Biology

Single-cell transcriptomics-guided development of flow cytometric tests predicting chronic myeloid leukemia blast crisis transformation at chronic phase diagnosis

Mengge Yu, Vaidehi Krishnan, Pavithra Shyamsundar, Kian Leong Lee, Florian Schmidt, Xi Ren, Charles T. H. Chuah, Shyam Prabhakar, Verity A Saunders, David T. O. Yeung, Naranie Shanmuganathan, Agnes S. M. Yong, Timothy P. Hughes, S. Tiong Ong

The paper develops flow cytometry tests to predict blast crisis transformation in chronic myeloid leukemia patients using single-cell transcriptomics insights.

bioRxiv · Jan 9, 2025 · PreprintCancer Biology

Robust clustering and interpretation ofscRNA-seq data using reference componentanalysis

Florian Schmidt, Bobby Ranjan, Quy Xiao Xuan Lin, Vaidehi Krishnan, Ignasius Joanito, Mohammad Amin Honardoost, Zahid Nawaz, Prasanna Nori Venkatesh, Joanna Hui Juan Tan, Nirmala Arul Rayan, S. Tiong Ong, Shyam Prabhakar

The paper introduces RCA2, a supervised clustering method for scRNA-seq data that is robust to batch effects and supports large-scale analysis.

bioRxiv · Feb 16, 2021 · PreprintBioinformatics