Author

Kian Leong Lee

National University of SingaporeORCID 0000-0002-0443-2746Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Kian Leong Lee1 paper

Biology Disciplines

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Cancer Biology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. Tiong OngiD· 3 shared Agnes S. M. YongiD· 2 shared Charles T. H. ChuahiD· 2 shared David T. O. YeungiD· 2 shared Naranie ShanmuganathaniD· 2 shared Timothy P. HughesiD· 2 shared Vaidehi KrishnaniD· 2 shared Verity A SaundersiD· 2 shared

Activity by Year

2019-2025 · peak 2/yr

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10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

S. Tiong OngORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 15, 2025

Mitochondrial DNA Mutations Determine Favourable Molecular Responses to Targeted Kinase Inhibitor Therapy and Impair Oxidative Phosphorylation

Ilaria Stefania Pagani, Vaidehi Krishnan, John F. Ouyang…·David M. Ross

This study shows that mitochondrial DNA mutations are linked to better responses to kinase inhibitor therapy and reduced oxidative phosphorylation in CML patients.

DOI 10.1101/2025.07.15.664865

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintJan 9, 2025

Single-cell transcriptomics-guided development of flow cytometric tests predicting chronic myeloid leukemia blast crisis transformation at chronic phase diagnosis

Mengge Yu, Vaidehi Krishnan, Pavithra Shyamsundar…·S. Tiong Ong

The paper develops flow cytometry tests to predict blast crisis transformation in chronic myeloid leukemia patients using single-cell transcriptomics insights.

1 citation

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Systems BiologybioRxivPreprintJul 5, 2019

Identification of drugs for leukaemia differentiation therapy by network pharmacology

Eleni G. Christodoulou, Lin Ming Lee, Kian Leong Lee…·Owen J. L. Rackham

The paper identifies drugs for leukaemia differentiation therapy using network pharmacology, finding that dimaprit and mebendazole enhance ATRA-mediated differentiation in leukaemia cells.

4 citations

humanbulk RNA-seq

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