Natural and patient-derived mutations in BK polyomavirus VP1 reveal structural determinants of BC-loop dependent antibody escape
Onno Akkermans, Cristina Ubeda Nicolau, Asanga Bandara, Consuelo C. Sierra, Fernando Henrique Martins, Steff De Graef, Erin E. Deans, Stephen J. Ross, S. Sienaert, Miriam Cerrada, Vipul Chimanlal Chitalia, Nagraj Mani, S.D. Weeks, Ali H. Munawar
The paper identifies BC-loop mutations in BKPyV VP1 that reduce antibody binding and neutralization, highlighting challenges for therapeutic development.
bioRxiv · Aug 9, 2025 · PreprintMicrobiology