A caspase-1-cathepsin AND-gate probe for selectiveimaging of inflammasome activation
Shiyu Chen, Una Goncin, Jiyun Zhu, Shih‐Po Su, Traci A. Czyzyk, Corin O. Miller, Raana Kashfi Sadabad, Matthew S. Bogyo
The paper designs a caspase-1-cathepsin AND-gate probe to selectively image inflammasome activation by requiring processing by both enzymes.
ACS Chemical Biology · Sep 30, 2025Peer-reviewedBiochemistry