Shiyu Chen

The paper designs a caspase-1-cathepsin AND-gate probe to selectively image inflammasome activation by requiring processing by both enzymes.

This paper develops a yeast display method to screen macrocyclic peptide libraries, enabling better selection and affinity ranking of ligands against diverse protein targets.

This paper develops polymer-tethered fluorescent probes for tumor-associated protease imaging, showing improved signal and tumor-to-background ratios compared to small molecule probes.