In vitro and in vivo derived macrophages occupy distinct phenotypic states
Stéphane Chevrier, Vito RT Zanotelli, Daniel Schulz, Mark D. Robinson, Laurie Ailles, Michael A.S. Jewett, Craig Gedye, Bernhard Reis, Bernd Bodenmiller
The paper compares in vitro and in vivo macrophage phenotypes using mass cytometry, finding distinct surface marker expression patterns between macrophages derived from culture and those from tumor-associated environments.
bioRxiv · Sep 20, 2025 · PreprintImmunology