Laurie Ailles

The paper integrates multi-modal data to identify immune subgroups in RCC and suggests immunotherapy strategies based on distinct T cell communication networks.

The paper shows humanized PDX models preserve tumour-specific immune microenvironments, supporting their use for studying immune evasion mechanisms.

This paper uses N-glycoproteomics to analyze patient-derived xenografts, identifies FAT2 as a therapeutic target for head and neck cancers, and validates its role in tumor growth and CAR T cell activity.

The paper compares in vitro and in vivo macrophage phenotypes using mass cytometry, finding distinct surface marker expression patterns between macrophages derived from culture and those from tumor-associated environments.

This study identifies SLC7A1 and arginine metabolism as a therapeutic vulnerability in high-grade serous ovarian cancer through surface proteomics and functional analysis.

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.