Stéphane Chevrier

Modular engineered colorectal tumor microenvironments for immuno-oncology research and drug development

This paper introduces SHOCOs, a modular system using patient-derived colorectal tumor organoids and fibroblasts to model tumor microenvironments, showing improved immune response and stromal effects on therapy.

Multimodal cell communication networks nominate immunotherapies for RCC subgroups with discrete T cell recruitment or expansion

The paper integrates multi-modal data to identify immune subgroups in RCC and suggests immunotherapy strategies based on distinct T cell communication networks.

Humanized patient-derived xenografts preserve tumour-specific immune microenvironments

The paper shows humanized PDX models preserve tumour-specific immune microenvironments, supporting their use for studying immune evasion mechanisms.

In vitro and in vivo derived macrophages occupy distinct phenotypic states

The paper compares in vitro and in vivo macrophage phenotypes using mass cytometry, finding distinct surface marker expression patterns between macrophages derived from culture and those from tumor-associated environments.

scROSHI - robust supervised hierarchical identification of single cells

scROSHI identifies cell types without training data by using pre-existing gene sets and hierarchical relationships, outperforming methods in low-data and high-diversity scenarios.

SCIM: Universal Single-Cell Matching with Unpaired Feature Sets

SCIM matches single-cell measurements across technologies by learning a technology-invariant latent space and applying bipartite matching, achieving high accuracy in real-world datasets.

Channel crosstalk correction in suspension and imaging mass cytometry

The paper introduces a bead-based compensation workflow for mass cytometry to correct channel crosstalk, improving data quality and panel development.