Author

Cristian Caloian

Ontario Institute for Cancer Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 3 Assay:whole-genome sequencing· 3 Approach:statistical model· 2 Organism:human· 1 Approach:simulation· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Joshua M. StuartiD· 3 shared Kathleen E. HoulahaniD· 3 shared Kyle EllrottiD· 3 shared Paul Christopher BoutrosiD· 3 shared Takafumi N. YamaguchiiD· 3 shared Adam A. Margolin· 2 shared Adam D. EwingiD· 2 shared Dorota H.S. SendorekiD· 2 shared

Activity by Year

2018-2018 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioinformatics

Joshua M. StuartORCID

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Author profile →

3 papers

Recent·Most cited

Combining accurate tumour genome simulation with crowd-sourcing to benchmark somatic structural variant detection

Anna Y. Lee, Adam D. Ewing, Kyle Ellrott, Yin Hu, Kathleen E. Houlahan, J Christopher Bare, Shadrielle M. G. Espiritu, Vincent Huang, Kristen Dang, Zechen Chong, Cristian Caloian, Takafumi N. Yamaguchi, ICGC-TCGA DREAM Somatic Mutation Calling Challenge Participants, Michael Kellen, Ken Chen, , Paul Christopher Boutros

The paper benchmarks somatic structural variant detection methods using synthetic tumors and crowd-sourced submissions, finding that ensembles do not always outperform individual methods.

Genome biology · Nov 6, 2018Peer-reviewedBioinformatics

Valection: Design Optimization for Validation and Verification Studies

SMC-DNA Challenge Participants, Christopher I. Cooper, Delia Yao, Dorota H.S. Sendorek, Takafumi N. Yamaguchi, Christine P’ng, Kathleen E. Houlahan, Cristian Caloian, Michael E. Fraser, Kyle Ellrott, Adam A Margolin, Robert Glen Bristow, Joshua M. Stuart, Paul Christopher Boutros

Valection optimizes the selection of verification candidates to estimate error profiles in genomics studies by evaluating different strategies on synthetic data.

BMC Bioinformatics · Sep 25, 2018Peer-reviewedBioinformatics

Germline Contamination and Leakage in Whole Genome Somatic Single Nucleotide Variant Detection

Dorota H.S. Sendorek, Cristian Caloian, Kyle Ellrott, J Christopher Bare, Takafumi N. Yamaguchi, Adam D. Ewing, Kathleen E. Houlahan, Thea Norman, Adam A. Margolin, Joshua M. Stuart, Paul Christopher Boutros

The paper quantifies germline leakage in somatic SNV detection across 259 datasets and introduces a tool to correct it, finding low leakage rates that can be further reduced with pre-filtering.

BMC Bioinformatics · Jan 31, 2018Peer-reviewedGenomics