Shadrielle M. G. Espiritu

This study maps epigenomic heterogeneity in prostate cancer by analyzing 3,001 methylomes and identifies four subtypes with distinct clinical and molecular features.

The paper benchmarks 31 subclonal reconstruction algorithms on simulated tumours, finding that algorithm choice significantly impacts performance and no single algorithm excels across all tasks.

This study develops quantitative metrics and simulated datasets to evaluate subclonal reconstruction methods in tumours.

This study uses a crowdsourcing approach to stratify ALS patients, identifying four distinct clusters with unique predictors and improving outcome prediction.

The paper benchmarks somatic structural variant detection methods using synthetic tumors and crowd-sourced submissions, finding that ensembles do not always outperform individual methods.

S22S is a reference-free method for somatic variant calling that uses genomic and population data to accurately identify SNVs without matched normal samples.