TL1A-activated T cells remodel the rectal mucosa in Crohn's disease patients with perianal fistulizing disease
Victòria Gudiño, Jae Won Cho, Berta Caballol, Ana Maria Corraliza, Marisol Veny, Isabella Dotti, Lívia Moreira Genaro, Ángela Sanzo-Machuca, Elisa Melón-Ardanaz, Maria Carme Masamunt, Míriam Esteller, Iris Teubel, Lisseth Robbins, Angel Giner, Cristina Prieto, , Azucena Salas
The paper identifies TL1A-driven cellular and transcriptomic changes in rectal mucosa of Crohn's disease patients with perianal fistulizing disease, revealing a novel TL1A-LT1{beta}2/IL-22 axis independent of TNF signaling.
bioRxiv · Jun 26, 2025 · PreprintImmunology