CRISPR-enabled genetic screens identify synthetic lethal targets across frequently altered cancer drivers
Jessica Desjardins, Julian Bowlan, Cynthia Bernier, Srishti Jain, Théo Goullet de Rugy, David Gallo, Mark E. Orcholski, Nancy Laterreur, Abira Rajah, Joshua Miller, Jennifer A. Lafontaine, Vivek Bhaskaran, Li Li, Alexanda K. Ling, Jesse H. Leblanc, , Jordan T.F. Young
This study identifies synthetic lethal interactions between cancer drivers and tractable targets using CRISPR screens and cancer dependency data, offering new drug targets for therapy.
bioRxiv · Jan 25, 2026 · PreprintCancer Biology