MULTIPLE DEFECTS IN MOUSE STEM CELL BASED EMBRYO MODELS LACKING ALL HOX FUNCTION
Hocine Rekaik, Lucille Lopez‐Delisle, Alexandre Mayran, Yuliia Romaniuk, Cynthia Diabanza, Anne-Catherine Cossy, Julie Gauvin, Denis Duboule
This study shows that mouse gastruloids lacking all HOX function can elongate but fail to form endoderm and properly segment mesoderm, suggesting HOX proteins are needed to posteriorize anterior structures.
bioRxiv · Jun 19, 2026 · PreprintDevelopmental Biology