Hocine Rekaik

This study shows that mouse gastruloids lacking all HOX function can elongate but fail to form endoderm and properly segment mesoderm, suggesting HOX proteins are needed to posteriorize anterior structures.

The paper investigates how CTCF sites in a DNA spacer delay Hoxb13 activation, affecting tail length by modulating its heterochronic expression.

The paper shows that conserved CTCF sites create sequential insulation, controlling the timing of Hox gene activation in pseudo-embryos through chromatin extrusion and cohesin loading.

The paper shows that Engrailed-1 protects dopaminergic neurons from degeneration by repressing LINE-1 expression, which is linked to oxidative stress-induced DNA damage.