Molecular BiologyNature CommunicationsPeer-reviewed
Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA
Déborah Bouvier, Juliette Ferrand, Odile Chevallier…·Sophie E. Polo
The paper identifies a non-canonical role of HIRA in transcription restart after DNA damage, independent of H3.3 deposition, by stabilizing UBN2 and reducing ATF3 expression.