Sophie E. Polo

The paper shows DNA methylation is largely maintained during UV damage repair through recruitment of DNMT1 and DNMT3A, driven by UHRF1 and repair endonucleases, and linked to histone dynamics and transcriptional response.

The paper uses proteomic profiling to identify DNAJC9 and MCM2 as key histone chaperones involved in chromatin repair during UV damage response in human cells.

This study identifies a mitotic chromatin-marking pathway that controls the asymmetric segregation of UV-induced DNA damage in human cells.

This study identifies the role of SPT2 in chromatin structure and function across Metazoa, showing its importance in germline development and chromatin accessibility.

The paper identifies a non-canonical role of HIRA in transcription restart after DNA damage, independent of H3.3 deposition, by stabilizing UBN2 and reducing ATF3 expression.

The paper investigates how heterochromatin maintains its structure and function after DNA damage using a mammalian cell system and real-time imaging.

The paper shows that the histone chaperone FACT deposits new H2A.X at DNA damage sites, facilitating repair and chromatin remodeling through interactions with ANP32E.