Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300
D. A. Davis, H. Bulut, P. Shrestha, A. Yaparla, H. K. Jaeger, S.-i. Hattori, P. Wingfield, H. Mitsuya, R. Yarchoan
This study shows that SARS-CoV-2 main protease (Mpro) activity and dimerization are regulated by reversible glutathionylation of Cys300, offering a new target for antiviral agents.
bioRxiv · Apr 9, 2021Microbiology