R. O. Williams

Feasibility of intranasal delivery of thin-film freeze-dried monoclonal antibodies

This paper demonstrates the feasibility of intranasally delivering monoclonal antibodies as dry powders using thin-film freeze-drying and the UDS Powder Nasal Spray System.

Feasibility of intranasal delivery of thin-film freeze-dried, mucoadhesive AS01B-adjuvanted vaccine powders

This study demonstrates that thin-film freeze-drying can convert a liquid vaccine into a dry powder with mucoadhesive properties, which can be effectively delivered using a nasal device for intranasal vaccination.

Aerosolizable plasmid DNA dry powders engineered by thin-film freezing

This study tests thin-film freezing to create aerosolizable plasmid DNA dry powders for pulmonary delivery, finding good aerosol performance and preserved pDNA integrity.

Accelerated mass transfer from frozen thin films during thin-film freeze-drying

This study demonstrates that thin-film freeze-drying (TFFD) significantly accelerates mass transfer compared to conventional freeze-drying, preserving bacterial viability and enabling efficient powder production.

Development of Dry Powder Formulations of AS01B containing vaccines using Thin-Film Freeze-Drying

This study demonstrates that thin-film freeze-drying can produce freezing-insensitive dry powders of AS01B-adjuvanted vaccines without compromising liposome integrity or immunogenicity.

Degradation of lactoferrin caused by droplet atomization process via two fluid nozzle: The detrimental effect of air water interfaces

This study investigates how the droplet atomization process in spray freeze-drying affects lactoferrin stability, finding that high air-water interfaces cause conformational changes and aggregation.

Dry Powders for Inhalation Containing Monoclonal Antibodies Made by Thin-Film Freeze-Drying

This paper demonstrates that thin-film freeze-drying produces stable aerosolizable dry powders of monoclonal antibodies for pulmonary delivery.

Formulation of Dry Powders of Vaccines Containing MF59 or AddaVax by Thin-Film Freeze-Drying

This study demonstrates that thin-film freeze-drying can convert MF59 or AddaVax-adjuvanted vaccines into dry powders while preserving immunogenicity and stability.

AUG-3387, a Human-Derived Monoclonal Antibody Neutralizes SARS-CoV-2 Variants and Reduces Viral Load from Therapeutic Treatment of Hamsters In Vivo

AUG-3387, a human monoclonal antibody, neutralizes SARS-CoV-2 variants and reduces viral load in hamsters when administered as a dry powder inhaler formulation.

Thin-Film Freeze-Drying of a Norovirus Vaccine Candidate

This study demonstrates that thin-film freeze-drying can convert a Norovirus vaccine into a stable dry powder without antigen loss, enabling cold chain elimination.

Selective Laser Sintering of a Photosensitive Drug: Impact of Processing and Formulation Parameters on Degradation, Solid-State, and Quality of 3D Printed Dosage Forms

This study investigates how processing and formulation parameters affect degradation, crystallinity, and quality of 3D-printed nifedipine dosage forms using selective laser sintering.

Niclosamide Inhalation Powder Made by Thin-Film Freezing: Pharmacokinetic and Toxicology Studies in Rats and Hamsters

This paper develops a niclosamide inhalation powder using thin-film freezing and tests its pharmacokinetics and toxicity in rats and hamsters for COVID-19 treatment.

Amorphous solid dispersions and the confounding effect of nanoparticles in in vitro dissolution and in vivo testing: Niclosamide as a case of study

This paper develops an amorphous solid dispersion of niclosamide, achieving increased bioavailability through nanoparticle formation, and validates its performance in vitro and in a rat model.

In Vivo Pharmacokinetic Study of Remdesivir Dry Powder for Inhalation in Hamsters

This study evaluates the pharmacokinetics of remdesivir dry powder for inhalation in hamsters, showing higher drug levels and suggesting a twice-daily dosing regimen.

Manufacturing Stable Bacteriophage Powders Using Thin Film Freeze-drying Technology

This paper demonstrates that thin film freeze-drying can produce stable bacteriophage powders suitable for inhalation therapy with minimal titer loss.

Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing

This paper develops a dry powder formulation of remdesivir for inhalation using thin film freezing, showing improved aerosol performance and lung delivery.