Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation
C. Galvagnion, S. Cerri, A. H. V. Schapira, F. Blandini, D. A. Di Monte
This study shows that the L444P GBA mutation in fibroblasts alters sphingolipid profiles, promoting α-synuclein aggregation through lipid-induced fibrillation.
bioRxiv · Nov 9, 2020Biochemistry