AICAR-mediated selection of karyotypically normal cells in Pallister-Killian syndrome patient-derived skin fibroblasts
E. Salzano, M. Kaur, A. M. Jacko, D. A. Mceldrew, S. E. Raible, I. D. Krantz, K. Izumi
This study shows AICAR selectively eliminates isochromosome 12p cells in PKS fibroblasts, suggesting a potential therapeutic strategy for aneuploidy disorders.
bioRxiv · Jan 27, 2022 · PreprintCell Biology