Author

K. Izumi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. G. O'Neill· 1 shared A. Kutomi· 1 shared A. L. Burrell· 1 shared A. L. Rippert· 1 shared A. M. Jacko· 1 shared D. A. Mceldrew· 1 shared E. Saho· 1 shared E. Salzano· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiochemistry

A. G. O'Neill

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Point mutations in IMPDH2 which cause early-onset neurodevelopmental disorders disrupt enzyme regulation and filament structure

A. G. O'Neill, A. L. Burrell, M. Zech, O. Elpeleg, T. Harel, S. Edvardson, H. M. Shaked, A. L. Rippert, T. Nomakuchi, K. Izumi, J. M. Kollman

The paper identifies two new IMPDH2 mutations linked to neurodevelopmental disorders and shows they disrupt GTP regulation and enzyme function through structural and functional analysis.

bioRxiv · Mar 15, 2023Biochemistry

AICAR-mediated selection of karyotypically normal cells in Pallister-Killian syndrome patient-derived skin fibroblasts

E. Salzano, M. Kaur, A. M. Jacko, D. A. Mceldrew, S. E. Raible, I. D. Krantz, K. Izumi

This study shows AICAR selectively eliminates isochromosome 12p cells in PKS fibroblasts, suggesting a potential therapeutic strategy for aneuploidy disorders.

bioRxiv · Jan 27, 2022 · PreprintCell Biology

Repertoire of morphable proteins in an organism

K. Izumi, E. Saho, A. Kutomi, F. Tomoike, T. Okada

The paper analyzes the structural variability of over a thousand E. coli proteins using a 'UnMorphness Factor' to understand the balance of rigidity and flexibility in an organism.

bioRxiv · Aug 5, 2019Biophysics