D. Asgari

Positioning of negative feedback loops within immune signaling pathways influences gene expression noise

The paper uses stochastic models to show how the location of negative feedback loops in immune signaling affects gene expression noise, finding that downstream loops reduce noise while upstream loops amplify it, which can be mitigated by strong positive feedback.

The role of uncertainty and negative feedback loops in the evolution of induced immune defenses

This study develops a mechanistic model of Drosophila immune signaling to show that induced defenses are favored under conditions of bacterial uncertainty and specific proliferation rates.

Gene expression in Lucilia sericata (Diptera: Calliphoridae) larvae exposed to Pseudomonas aeruginosa and Acinetobacter baumanii identifies shared and microbe-specific induction of immune genes