Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates
D. Bae, R. E. Jones, K. M. Piscopo, M. Tyagi, J. D. Shepherd, J. Hollien
The paper shows that IRE1-mediated degradation of Blos1 prevents mHTT aggregation by promoting endosomal microautophagy, protecting cells from toxic mHTT forms.
bioRxiv · Sep 28, 2021Cell Biology