p53 mutations exhibit sex specific gain-of-function activity in gliomagenesis
N. C. Rockwell, W. Yang, N. Warrington, M. Griffith, O. L. Griffith, C. Gurnett, B. Cohen, D. Baldridge, J. B. Rubin
This study identifies sex-specific gain-of-function activity of p53 mutations in glioblastoma, showing mutation-specific differences in transforming astrocytes and altering gene expression patterns.
bioRxiv · Jun 11, 2021 · PreprintCancer Biology