J. B. Rubin

Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma

The paper shows that gonadal sex influences p21-induced cellular senescence in GBM, contributing to sex differences in survival.

Mapping multiregional imaging-localized biopsies to MRI habitats reveals biologically significant glioma tissue states and associated patterns of cohabitating cellular subpopulations

The paper maps MRI-localized glioma biopsies to MRI habitats, identifying transcriptional tissue states and their association with cellular subpopulations and MRI features.

De novo serine biosynthesis from glucose predicts sex-specific response to antifolates in non-small cell lung cancer cell lines

The paper shows male NSCLC cells produce more serine from glucose and are more sensitive to pemetrexed than female cells, suggesting sex differences in antifolate response.

Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment

The paper identifies sex differences in glutamine metabolism in glioblastomas, showing male tumors have higher glutamine uptake and are more sensitive to GLS1 inhibition than female tumors.

p53 mutations exhibit sex specific gain-of-function activity in gliomagenesis

This study identifies sex-specific gain-of-function activity of p53 mutations in glioblastoma, showing mutation-specific differences in transforming astrocytes and altering gene expression patterns.

JAM-A functions as a female microglial tumor suppressor in glioblastoma

This study shows that JAM-A deficiency in female mice increases microglia activation and GBM growth, revealing a sex-specific role for JAM-A in the tumor microenvironment.

Sex differences in seizure at presentation in glioma population

This study examines the association between tumor location and seizure risk in male and female glioma patients.

Sex Differences in Predictors of Seizure in Contrast-Enhancing Gliomas at Clinical Presentation: A Network Approach

The paper uses a machine learning model to predict seizure risk in glioma patients at presentation, finding sex, tumor size, and age as significant predictors.

Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

This study identifies sex-specific predictors of survival in glioblastoma patients using MR imaging and clinical data.

Temporal and Clonal Progression in a Pediatric Ependymoma Patient Through Multiple Treatments

This study tracks the molecular evolution of a pediatric ependymoma through multiple treatments, revealing how therapy shapes tumor subclonal diversity and neo-antigen landscapes.