Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β
M. Zigdon, J. Sawaed, L. Zelik, D. Binyamin, S. Ben-Simon, N. Asulin, R. Levin, S. Modilevsky, M. Naama, S. Telpaz, E. Rubin, A. Awad, W. Sawaed, S. Harshuk-Shabso, M. Nuriel-Ohayon, , S. Bel
This study shows that IL-1β production during Salmonella infection is harmful, reducing neutrophil recruitment and inhibiting Salmonella expansion by altering epithelial cell metabolism and complement system interactions.
bioRxiv · Jun 14, 2023Immunology